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Symptoms: Large doses produce respiratory depression and hypertension with circulatory failure and deepening coma.
Treatment: Correct respiratory failure and shock with intensive supportive therapy. In addition, the specific antagonist naloxone hydrochloride is used to counter react very rapidly the severe respiratory depression and coma produced by excessive doses of morphine. A dose of 0.4 to 2 mg of Naloxone Hydrochloride is given by I/V injection repeated at intervals of 2 to 3 minutes, if necessary up to 10 mg. May also be given by subcutaneous or I/M injection or I/V infusion.
